using System;

​

public class Program

{

    public static void Main()

    {

        var test = new Derived();

        Type t = test.GetType();

        bool isIt =  t.IsSubclassOf(typeof(MyGeneric<>));

        Console.WriteLine(isIt);

        isIt = test.GetType().IsSubclassOf(typeof(MyGeneric<int>)); 

        Console.WriteLine(isIt);

        isIt = test.GetType().GetGenericTypeDefinition().IsSubclassOf(typeof(MyGeneric<>));

        Console.WriteLine(isIt);

    }

}

​

public class Derived : MyGeneric<int>

{

}

​

public class MyGeneric<T>

{

    public T Val {get; set;}

}