using System;

using System.Reflection;

abstract class A<T>

{

    public abstract void DoSomething(string asd, T obj);

}

​

class MyClass : A<int>

{

    public override void DoSomething(string asd, int obj)

    {

        Console.WriteLine(obj);

    }

}

​

public class Program

{

    public static void Main(string[] args)

    {

        Type unboundGenericType = typeof(A<>);

        Type boundGenericType = unboundGenericType.MakeGenericType(typeof(int));

        Type myClassType = typeof(MyClass);

        object instance = Activator.CreateInstance(myClassType);

        MethodInfo doSomethingMethod = boundGenericType.GetMethod("DoSomething");

        doSomethingMethod.Invoke(instance, new object[] {"Hello", 123});

    }

}

​