Imports System

Imports System.Xml

Imports System.Xml.Linq

Public Module Module1

    Public Sub Main()

        Dim rawXml = <DataPaths>

  <TableData>

    <ID>10</ID>

    <TablePath>C:\Users\Tom\Test.xls</TablePath>

    <TableName>TestName</TableName>

    <Mode>TestMode</Mode>

  </TableData>

</DataPaths>

        Dim XmldocDel As New XmlDocument()

        XmldocDel.LoadXml(rawXml.ToString())

        Dim node As XmlNode

        node = XmldocDel.SelectSingleNode("//DataPaths/TableData[ID = '10']")

        If node IsNot Nothing Then

            node.ParentNode.RemoveChild(node)

            Console.WriteLine(XmldocDel.OuterXml)

        Else

            Console.WriteLine("No node found")

        End If

    End Sub

End Module